Combat ends with first strike

Bloodartist wrote:

Question: Does a strike:combat end when done with first strike resolve earlier than a combat end done normally? And would this cancel the effects of the 'normal' S:CE?

No, all S:CE resolve at the same time, regardless they have First Strike or not:

rulebook wrote:

First Strike. A strike done with first strike is resolved before a normal strike.
Combat Ends. This effect ends combat immediately. This type of strike is always the first to resolve, even before a strike done with first strike, and it ends combat before other strikes or other strike resolution effects are resolved.

Also, a S:CE by itself can't cancel the effect of another S:CE. The exception is when the additional effects of the two S:CE are in contradiction (for instance, Form of Mist that allows to continue the action vs Blissful Agony that starts a new combat).

Blissful Agony
[ani] Strike: hand strike at +1 damage.
[val] Only usable at close range before strikes are chosen. The opposing minion takes 1 unpreventable damage each round this combat during normal strike resolution at close range. A vampire can play only one Blissful Agony at [val] each combat.
[VAL] Strike: combat ends. Choose a minion controlled by a Methuselah other than the opposing vampire's controller. The opposing vampire and that minion enter combat.

Form of Mist
[pro] Strike: dodge.
[PRO] Strike: combat ends. If this vampire is acting and needs stealth when this strike resolves, he or she can burn 1 blood after combat ends to continue the action at +1 stealth as if unblocked. A vampire can play only one Form of Mist at superior each action.

Bloodartist wrote:

ps. One thing though for future reference: how would the situation change if either combatant uses a hand strike: combat end? For example anesthetic touch or autonomic mastery? ie. Hand strike:CE vs normal combat end; or hand strike:CE with first strike vs hand strike:CE

There's no such thing as a hand strike: combat ends.

Anesthetic Touch
Only usable at close range.
[aus] Strike: dodge.
[obe] Strike: hand strike. Combat ends immediately after the resolution of this strike.
[OBE] As [obe] above, with first strike.

Autonomic Mastery
Only usable at close range.
[dom] Strike: burn the opposing non-wraith ally or a non-wraith retainer on the opposing minion.
[DOM] Strike: hand strike. This strike inflicts no damage. Combat ends immediately after strike resolution, unless it is dodged. Only usable in combat with a non-wraith ally or a younger.

Both effects are strike: hand strike and are handled accordingly. They don't reach resolution against a S:CE and they have an additional effect which is never resolve neither.

So basically, if A plays a S:CE and B a Anesthetic Touch at superior, A's strike resolves first and B's strike never resolves.

rulebook wrote:

Combat Ends. This effect ends combat immediately. This type of strike is always the first to resolve, even before a strike done with first strike, and it ends combat before other strikes or other strike resolution effects are resolved.

If A plays an Autonomic Mastery and B an Anesthetic Touch at [obe], both strikes resolves simulateanously (A and B suffer strength damage from the opponent) and combat ends after that.
If A plays an Autonomic Mastery and B plays Anesthetic Touch at [OBE], then B's strikes resolves first, inflicting strength damage, and combat ends before A's strike resolves.